Islet cell cytoplasmic antibody reactivity in midgestational human fetal pancreas
نویسندگان
چکیده
منابع مشابه
Pancreas and islet cell transplantation.
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring beta-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a su...
متن کاملReactivity of pancreas islet cells with antisera of known specificity.
I N NON-MHC (major histocompatibility complex) as well as in MHC fully allogeneic rat strain combinations, islet grafts are very often as rapidly rejected as skin grafts. Among the many attempts to reduce islet immunogenicity, there are promising studies such as the in vitro culture of islet grafts prior to transplantation,l namely, the elimination of la-bearing cells from murine islets with an...
متن کاملIslet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.
Individuals with or at risk for insulin-dependent diabetes (IDD) frequently have autoantibodies against an islet cell cytoplasmic (ICA) antigen thought to be a sialoglycolipid. However, we now report that preabsorption of ICA-positive sera with recombinant glutamate decarboxylase (human GAD 65 and/or GAD 67) reduced or blocked the ICA reactivity of 5/18 (27%) new-onset IDD patients and 7/18 (39...
متن کاملFetal Pancreas as a Source for Islet Transplantation
The early hope that islet transplantation might offer an attractive treatment modality for latestage type 1 diabetes has been tempered over the last decade, largely due to the observation that the transplants exhibit reduced insulin production after a few years (1). This limitation could be associated with some form of immune rejection or the inability of the implanted islets to replenish dying...
متن کامل[Islet cell tumor of the pancreas].
Insulin-secreting tumours of the pancreas may present considerable problems in diagnosis and not a little difficulty in treatment. If the possibility of hypoglycaemia being the cause of attacks of altered consciousness associated with autonomic disturbance is thought of, it is not difficult to demonstrate its existence, but it is more difficult to demonstrate with certainty that such hypoglycae...
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ژورنال
عنوان ژورنال: Acta Diabetologica
سال: 1994
ISSN: 0940-5429,1432-5233
DOI: 10.1007/bf00571957